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085235|制药工程专业硕士研究生指导教师ClickNum:360
姓名 江成世 性别
民族汉族出生年月1985-6
学历|学位研究生|博士专业技术职务 副教授(校聘A3)
行政职务
联系电话18306445023移动电话18306445023
邮箱jiangchengshi-20@163m
通讯地址 | 邮编山东省济南市南辛庄西路336号济南大学生物科学与技术学院 | 250022
招生方向(领域) 01(全日制)天然产物与药物化学
研究领域、学习工作经历、学术兼职等情况

研究方向:药物合成、活性天然产物的合成与结构修饰

江成世,男,1985年6月生,副教授,硕士研究生导师。2012年毕业于中国科学院上海药物研究所,获理学博士学位。2011年11月至2012年5月参加欧盟第七框架中欧合作项目,在意大利University of NaplesFederico II药学院从事海洋活性天然产物的分离与结构鉴定研究。2012年7月至2014年7月在中国科学院上海药物研究所任助理研究员;2014年8月至今于济南大学生物科学与技术学院工作。2015年8月至2016年8月于巴西利亚大学生科院从事基于光动力学抗肿瘤纳米粒子研究。目前,作为项目负责人主持国家自然科学项目两项以及上海市科委项目一项。

长期致力于具有抗肿瘤、抗老年痴呆及酶抑制作用的活性天然产物的合成、结构修饰与构效关系研究,在该领域取得了许多重要研究成果。近五年来,已发表SCI收录论文17篇,其中第一作者11篇,包括Chem. Rev., Bioorg. Med. Chem. Lett., Steroids等本学科主流国际期刊。2012年获得中国科学院对优秀毕业生的最高奖励“中国科学院院长优秀奖”、2013年获得上海市药学会海洋药物青年报告一等奖、参与完成的《中国红树林植物及其共/附生微生物的化学成分及生物活性研究》获得2014年度上海药学科技奖二等奖。

 
代表性科研成果及奖励:
(包括项目、鉴定、论文、专著、专利等)

承担项目:

  1. 新型非甾体类盐皮质激素受体拮抗剂-(3R)--O-甲基毛狄泼老素类似物的设计、合成及其构效关系研究,编号:81302692,国家自然科学基金青年项目,2014.01-2016.1223万,项目负责人,在研;

  2. 海洋来源的3,5-二取代恶二唑类神经保护剂的成药性研究,编号:14431901100,上海市科研计划项目,2014.07-2017.0940万,项目负责人,在研。

  3. 海洋天然产物Hyrtioseragamine B的合成、结构修饰及其多靶向抗阿尔茨海默症构效关系研究,编号:21672082,国家自然科学基金面上项目,2017.01-2020.12,63万,项目负责人

科研论文:

  1. Cheng-Shi Jiang, Werner E. G. Muller, Heinz C. Schroder, and Yue-Wei Guo*. Disulfide- and Multisulfide-Containing Metabolites from Marine Organisms. Chem. Rev. 2012, 112, 2179–2207. (SCI, IF = 41.298)

  2. Li Zhang, Cheng-ShiJiang (co-first author), Li-Xin Gao, Jing-Xu Gong, Zhong-Hua Wang,Jing-Ya Li, Jia Li, Xu-Wen Li, Yue-Wei Guo. Design, synthesis and in vitroactivity of phidianidine B derivatives as novel PTP1B inhibitors with specificselectivity. Bioorg. Med. Chem. Lett., 2016,26, 788-781. (SCI, IF=2.42)
  3. Jia-Cheng Li, Juan Zhang, Mosar Corrêa Rodrigues,De-Jun Ding, João Paulo Figueiró Longo, Ricardo Bentes Azevedo, Luis AlexandreMuehlmann, Cheng-Shi Jiang*. Synthesisand evaluation of novel 1,2,3-triazole-based acetylcholinesterase inhibitorswith neuroprotective activity. Bioorg. Med. Chem. Lett., 2016, 26, 3881-3885. (SCI, IF=2.486)
  4. Graziella A Joanitti, Rayane Ganassin, Mosar R Correa,Joao PF Longo, Cheng-Shi Jiang, Jin-Song Gu, Sandra ML Pinto,Maria Santos, Ricardo Betes Azevedo, Luis A Muehlmann. Nanostructured systems forthe organelle-specific delivery of anticancer drugs. Mini-Rev. Med. Chem.,2016, DOI: 10.13140/RG.2.1.4334.9365. (SCI, IF=2.90)
  5. Cheng-Shi Jiang,Yan Fu, Li Zhang, Jing-Xu Gong, Zhen-Zhong Wang, Wei Xiao*, Hai-Yan Zhang*, Yue-WeiGuo*. Synthesis and biological evaluation of novel marine-derived indole-based1,2,4-oxadiazoles derivatives as multifunctional neuroprotective agents.Bioorg. Med. Chem. Lett., 2015, 25, 216-220. (SCI, IF=2.42)
  6. Jing Chen, Li-Xin Gao,Jing-Xu Gong, Cheng-Shi Jiang,Li-Gong Yao, Jing-Ya Li, Jia Li, Wei Xiao, Yue-Wei Guo*. Design and Synthesisof novel 1,2-dithiolan-4-yl benzoate derivatives as PTP1B inhibitors. Bioorg.Med. Chem. Lett., 2015, 25, 2211-2216. (SCI, IF= 2.42)
  7. Jing Xu, Cheng-Shi Jiang (co-first author), Zai-Long Zhang, Wen-Quan Ma, Yue-Wei Guo*. Recent progress regarding the bioactivities, biosynthesis and synthesis of naturally occuring resorcinolic macrolides. Acta Pharmacol. Sin. 2014, 35, 316–330. (SCI, IF = 2.354)

  8. Ji-Zhen Sun, Cheng-Shi Jiang, Xue-Qin Chen, Kao-Shan Chen, Xue-Chu Zhen, Rob W.M. van Soest, Yue-Wei Guo. Topsendines A-F, new 3-alkylpyridine alkaloids from a Hainan sponge Topsentia sp. Tetrahedron 2014, 70, 3166–3171. (SCI, IF = 2.803)

  9. Cheng-Shi Jiang, Yan Li, Bing Wang,Wen-Quan Ma, Yue-Wei Guo*. Further new casbane-type diterpene from soft coral Sinularia depressa. Chin. J. Nat. Med. 2014, accepted. (SCI, IF = 1.11)

  10. Jing Li, Jun Wang, Cheng-Shi Jiang, Gang Li, Yue-Wei Guo*.  (+)-Cyclopenol, a new 7-membered 2,5-dioxopiperazine alkaloid from Penicillium sclerotiorum endogenous with the Chinese mangrove Bruguiera gymnorrhiza. J. Asian. Nat. Prod. Res. 2014, 16, 542-548. (SCI, IF = 0.984)

  11. Li-Li Wang, Cheng-Shi Jiang (co-first author), Yan Fu, Fei-Fei Chen, Le-Fu Lan, Hai-Yan Zhang, Yue-Wei Guo*. Two new limonoids from the root barks of Dictamnus dasycarpus. Helv. Chim. Acta. 2014, Accepted. (SCI, IF = 1.383)

  12. Jing Chen, Cheng-Shi Jiang (co-first author), Wen-Quan Ma, Li-Xin Gao, Jing-Xu Gong, Jing-Ya Li, Jia Li, Yue-Wei Guo*. The first synthesis of natural disulfide bruguiesulfurol and biological evaluation of its derivatives as a novel scaffold for PTP1B inhibitors. Bioorg. Med. Chem. Lett. 2013, 23, 5061-5065. (SCI, IF = 2.338)

  13. Cheng-Shi Jiang, Yan Li, Zhen-Zhong Wang, Xiao-Yin Huang, Wei Xiao, Yue-Wei Guo*. Cipatrijugin G, a new trijugin-type limonoid bearing an uncommon γ-hydroxybutenolide unit from the aerial parts of Cipadessa cinerascens. Nat. Prod. Bioprospect. 2013, 23, 5061–5065.

  14. Rong Zhou, Zhong-Hui Lin, Cheng-Shi Jiang, Jing-Xu Gong, Li-Li Chen, Yue-Wei Guo*, Xu Shen*. Marine natural product des-O-methyllasiodiplodin effectively lowers the blood glucose level in db/db mice via ameliorating inflammation. Acta Pharmacol. Sin. 2013, 34, 1325–1336. (SCI, IF = 2.354)

  15. Cheng-Shi Jiang, Xian-Jun Guo, Jing-Xu Gong, Ting-Ting Zhu, Hai-Yan Zhang*, Yue-Wei Guo*. Synthesis and biological evaluation of 21-arylidenepregnenolone derivativesas neuroprotective agents. Bioorg. Med. Chem. Lett. 2012, 22, 2226–2229. (SCI, IF = 2.338)

  16. Cheng-Shi Jiang, Lin-Fu Liang, Yue-Wei Guo*. Natural products possessing protein tyrosine phosphatase 1B (PTP1B) inhibitory activity found in the last decades. Acta Pharmacol. Sin. 2012, 33,1217–1245. (SCI, IF = 2.354)

  17. Cheng-Shi Jiang, Rong Zhou, Jing-Xu Gong, Li-Li Chen, Tibor Kurtán, Xu Shen, Yue-Wei Guo*. Synthesis, modification, and evaluation of (R)-de-O-methyllasiodiplodin and analogs as nonsteroidal antagonists of mineralocorticoid receptor. Bioorg. Med. Chem. Lett. 2011, 21, 1171–1175. (SCI, IF = 2.554)
  18. Cheng-Shi Jiang, Yue-Wei Guo*. Epipolythiodioxopiperazine from Fungi: Chemistry and Bioactivities. Mini-Rev. Med. Chem. 2011, 11, 728–745. (SCI, IF = 2.582)

  19. Cheng-Shi Jiang, Cai-Guo Huang, Bo Feng, Jia Li, Jing-Xu Gong, Tibor Kurtán, Yue-Wei Guo. Synthesis and antitumor evaluation of methyl spongoate analogs. Steroids. 2010, 75, 1153–1163. (SCI, IF = 3.106)


专利发明:

  1. 一种具有1,2,3-三氮唑结构片段的生物碱化合物及其用途。江成世,张华,张娟,刘娜,李家诚。申请号:2016.10281376.3
  2. 一类具有1,2,4-恶二唑片段结构的吲哚生物碱及其制备方法和用途。郭跃伟,章海燕,萧伟,王振中,江成世,傅燕。申请号:2014102559602

  3. 3-羟基-孕甾-21-(2′,5′-二甲氧基)苯亚甲基-5--20-酮、其制备方法和用途。郭跃伟,章海燕,江成世,傅燕。申请号:201110175742.4

  4. (3R)--O-甲基毛狄泼老素在制备预防或治疗抑郁症的药物中的用途。章海燕,郭跃伟,唐希灿,龚景旭,王维,江成世。申请号:201110079284.4

  5. 一种具有胰脂肪酶抑制活性的苯并大环内酯类化合物及其合成方法和用途。郭跃伟,王贺瑶,龚景旭,张小东,江成世。申请号:200910201463.3

     

获奖情况:

  1. 2013年第二届上海市海洋药物青年论文报告会优秀论文一等奖;

  2. 2013年上海药物所科技能手荣誉称号;

  3. 2012年中国科学院院长优秀奖;

  4. 20122011年度中科院三好学生;

  5. 2007年曲阜师范大学优秀毕业论文;

  6. 2007年曲阜师范大学优秀生。

著作情况:

  1. 编写全国高职高专十二五规划教材《天然药物化学》第十一章海洋天然产物。

  2. 参与编写《海洋生物资源开发利用新技术丛书》之《海洋天然产物与药物研究开发》第一章海洋动物来源天然产物研究开发”。
  3. eBook series - Recent Advances in Medicinal Chemistry 2015,Vol. 2, 3-39,"Epipolythiodioxopiperazine from Fungi: Chemistry and Bioactivities". Publishing.





教学及研究生培养情况

承担本科生课程:物理化学、物理化学实验

 
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